KMID : 0624620110440070452
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BMB Reports 2011 Volume.44 No. 7 p.452 ~ p.457
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Estrogen receptor ¥â stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells
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Kim Ji-Hae
Jeong Il-Yeup Lim Yoong-Ho Lee Young-Han Shin Soon-Young
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Abstract
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The Egr-1 is an immediate early response gene encoding a transcription factor that functions in the regulation of cell growth, differentiation, and apoptosis. Estrogen has diverse physiological effects, including cellular proliferation and neuroprotection against brain injury. There are two types of estrogen receptors (ERs), ER¥á and ER¥â. ER¥á-induced Egr-1 expression has been extensively studied; however, the role of ER¥â is yet not known. In the present study, we investigated whether or not ER¥â induces Egr-1 expression in C6 rat glioma cells, which express ER¥â but not ER¥á. Our results show that ER¥â promoted up-regulation of Egr-1 expression via a non-genomic mechanism involving the Raf/MEK1/Erk/Elk-1 signaling cascade.
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KEYWORD
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C6 glioma, Egr-1, Estrogen receptor ¥â, MAPK, 17¥â-estradiol
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